...and whilst still on the topic of shutdown DNA...it is amazing what dentists can do, nowadays - isn't it, dazzlenation?...see previous post...go figure:

 

https://en.wikipedia.org/wiki/Angelman_syndrome

https://en.wikipedia.org/wiki/Angelman_syndrome#/media/File:Ritratto_di_fanciullo_con_disegno_Giovanni_Francesco_Caroto.jpg